Biochemical and Biophysical Journal of Neutron Therapy & Cancer Treatments

نویسندگان

  • Chong Sun
  • Kamia Punia
  • Andrew Mancuso
  • Sukanta Dolai
  • Jimmie E. Fata
  • Mario R. Castellanos
  • Krishnaswami Raja
چکیده

Curcumin, which has been used in ancient Indian Ayurvedic system of medicine, has recently been shown to have anti-cancer activity. However, its poor solubility in water has restricted its development as an effective anti-cancer agent for clinical use. We report the synthesis of a well-defined water soluble Bovine Serum Albumin (BSA)-curcumin conjugate. The conjugate was characterized via Gel electrophoresis and Fast Protein Liquid Chromatography (FPLC). The drug loading was determined by MALDI-TOF. The potent anti-cervical cancer activity was validated by cytotoxicity properties against the HeLa cancer cell line via the MTT assay.

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تاریخ انتشار 2014